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Objective@#To investigate the prevalence of autonomic dysfunction and its influencing factors in the elderly in Jizhou community of Tianjin.@*Methods@#By using a cross-sectional study, a questionnaire survey was conducted in the elderly in order to investigate the prevalence of autonomic dysfunction and its influencing factors.@*Results@#A total of 1 292 elderly patients were enrolled.Of them, 196 cases had autonomic dysfunction(15.2%, 196/1 292). The main symptoms of autonomic dysfunction were frequent urination, urination urgency, urination incontinence(19.7%, 255/1 292)and constipation(15.9%, 205/1 292). Multivariate Logistic regression analysis showed that women(OR=1.808, 95%CI: 1.253~2.607), 75-85 years of age(OR=1.573, 95%CI: 1.109~2.232), general anesthesia history(OR=1.552, 95%CI: 1.044~2.307), sleep disorders(OR=2.906, 95%CI: 1.506~2.916), diabetes(OR=1.791, 95%CI: 1.197~2.678)and headache(OR=2.589, 95%CI: 1.482~4.520)were risk factors for autonomic dysfunction.@*Conclusions@#The prevalence of autonomic dysfunction is high in the elderly in Jizhou community of Tianjin city.It is necessary to pay great attention to potential risk factors of autonomic dysfunction in the elderly.And the autonomic dysfunction symptoms should be diagnosed and treated as early as possible.
ABSTRACT
Objective To investigate the prevalence of autonomic dysfunction and its influencing factors in the elderly in Jizhou community of Tianjin.Methods By using a cross-sectional study,a questionnaire survey was conducted in the elderly in order to investigate the prevalence of autonomic dysfunction and its influencing factors.Results A total of 1 292 elderly patients were enrolled.Of them,196 eases had autonomic dysfunction(15.2％,196/1 292).The main symptoms of autonomic dysfunction were frequent urination,urination urgency,urination incontinence (19.7 ％,255/1 292) and constipation(15.9 ％,205/1 292).Multivariate Logistic regression analysis showed that women(OR =1.808,95 ％CI:1.253 ～ 2.607),75-85 years of age (OR =1.573,95 ％ CI:1.109 ～ 2.232),general anesthesia history(OR =1.552,95％CI:1.044～2.307),sleep disorders(OR =2.906,95％CI:1.506 ～2.916),diabetes(OR =1.791,95％CI:1.197～2.678) and headache(OR =2.589,95％CI:1.482～4.520)were risk factors for autonomic dysfunction.Conclusions The prevalence of autonomic dysfunction is high in the elderly in Jizhou community of Tianjin city.It is necessary to pay great attention to potential risk factors of autonomic dysfunction in the elderly.And the autonomic dysfunction symptoms should be diagnosed and treated as early as possible.
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Objective To investigate the neuroprotective effects of Fasudil in cerebral I/R injury in mice.Methods 51 C57BL/6J mice was divided into two groups,CMC treated group (n=26) and Fasudil treated group (n=25),randomly.The mice were treated with Fasudil (10 mg/kg) or CMC (0.5％ CMC 10 ml/kg) separately.Then the treated mice were subjected to 60 min of focal ischemia and 18 h reperfusion.The infarct volume of brain was analyzed by TTC staining with MCID image system.BBB permeability was assessed by Evans blue extravasation and albumin leakage which was detected by immuno-blotting assay.The activity of MMP9 was analyzed by zymography.Results The infarct volume in CMC group ((99.07±6.53) mm3) was larger than that in Fasudil group ((57.02±8.93) mm3),the difference was statistically significant (P＜0.01).The activity of MMP9 in the mice treated with Fasudil was lower than that in CMC group.Compared with the CMC group(albumin (2.95±0.77),Evans blue (5.15±0.24)),the albumin and Evans blue content in the Fasudil treated group (albumin (1.04±0.18),Evans blue (1.96±0.31))reduced significanctly(all P＜0.01).Conclusion Fasudil protects I/R damage by inhibiting the activity of MMP9 to maintain blood-brain barrier permeability.
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In 42 cases of depression treated by acu puncture therapy plus Tuina therapy, the results showed cure in 23 cases, remarkable effect in 17 cases and failure in 2 cases.